Ophthalmic Compositions Containing A Synergistic Combination of Two Polymers
AssigneeNovartis AG
InventorsMasood A. Chowhan, Huagang Chen
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Abstract
Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of two polymers that have a synergistic effect on viscosity.
Claims20
An aqueous composition suitable for ophthalmic administration comprising a viscosity enhancing amount of combination of two polymers having a synergistic effect on the composition's viscosity and wherein the combination of two polymers is selected from the group consisting of hydroxypropyl methylcellulose and guar gum;
- hydroxypropyl methylcellulose and a carboxyvinyl polymer;
- a carboxyvinyl polymer and guar gum;
- hydroxypropyl methylcellulose and hydroxyethylcellulose;
- hyaluronic acid and hydroxypropyl methylcellulose;
- hyaluronic acid and a carboxyvinyl polymer;
- and hyaluronic acid and guar gum, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid.
A method of alleviating the symptoms of dry eye comprising topically administering to the eye an aqueous composition comprising a viscosity enhancing amount of a combination of two polymers having a synergistic effect on the composition's viscosity and wherein the combination of two polymers is selected from the group consisting of hydroxypropyl methylcellulose and guar gum;
- hydroxypropyl methylcellulose and a carboxyvinyl polymer;
- a carboxyvinyl polymer and guar gum;
- hydroxypropyl methylcellulose and hydroxyethylcellulose;
- hyaluronic acid and hydroxypropyl methylcellulose;
- hyaluronic acid and a carboxyvinyl polymer;
- and hyaluronic acid and guar gum, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid.
A method of treating a disease or condition of the eye comprising administering to the eye a composition comprising an ophthalmic drug and a carrier wherein the carrier comprises a viscosity enhancing amount of a combination of two polymers having a synergistic effect on the composition's viscosity and wherein the combination of two polymers is selected from the group consisting of hydroxypropyl methylcellulose and guar gum;
- hydroxypropyl methylcellulose and a carboxyvinyl polymer;
- a carboxyvinyl polymer and guar gum;
- hydroxypropyl methylcellulose and hydroxyethylcellulose;
- hyaluronic acid and hydroxypropyl methylcellulose;
- hyaluronic acid and a carboxyvinyl polymer;
- and hyaluronic acid and guar gum, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid.
Dependencies are inferred from the claim text.