Device for transdermal administration of drugs including acrylic based polymers
AssigneeNoven Pharmaceuticals, Inc.
InventorDavid Kanios
Life of this patent
Estimating the term…
Abstract
A transdermal delivery system is provided where the drug delivery rates, onset and profiles of at least one active agent are controlled by selectively manipulating the monomeric make up of an acrylic-based polymer in the transdermal drug delivery system. The drug carrier composition may be comprised of (a) one or more acrylic-based polymers having one or more different monomers selected from the group consisting of hard and soft monomers; (b) one or more silicone-based polymers; and (c) one or more active agents where the device provides a desired solubility for the active agent and controls drug delivery rates, onset and profiles of at least one active agent.
Claims24
1-19. (canceled)
A method of making a transdermal drug delivery system comprising, forming a carrier composition comprising a blend of
- (a) a polymer composition comprising at least one acrylic-based polymer polymerized from monomers that consist of:
- (i) soft acrylic monomers selected from the group consisting of 2-ethyl hexyl acrylate, isobutyl acrylate, ethyl acrylate, butyl acrylate, dodecyl methacrylate, 2-ethylhexyl methacrylate, 2-ethoxyethyl acrylate, isopropyl acrylate, and 2-methoxyethyl acrylate, in an amount of 20% by weight of the acrylic-based polymer;
- and (ii) hard acrylic monomers selected from the group consisting of methacrylate, N-butyl acrylate, acrylic acid, butyl methacrylate, ethyl methacrylate, methyl methacrylate, hexyl methacrylate, and methyl acrylate, in an amount of 80% by weight of the acrylic-based polymer;
- and
- (b) a drug in an amount of from 0.1% to 50% by weight of the carrier composition, wherein all acrylic-based polymers present in said polymer composition of the transdermal drug delivery system are polymerized from monomers that consist of monomers selected from the group consisting of said soft and hard acrylic monomers (i) and (ii).
A method of making a transdermal drug delivery system comprising, forming a carrier composition comprising a blend of:
- (a) a polymer composition of at least one acrylic-based polymer which acrylic-based polymer is polymerized with monomers that include:
- (i) a soft acrylic monomer having a glass transition temperature (Tg) from about −70 C to about −10 C in an amount of from about 20 to about 70% by weight of the acrylic-based polymer;
- and (ii) a hard acrylic monomer having a glass transition temperature (Tg) from about −5 C to about 120 C in an amount of from about 30 to about 80% by weight of the acrylic-based polymer,
- wherein said acrylic based polymers are not polymerized with methacrylic acid monomers;
- and
- (b) a drug in an amount of from 0.1% to 50% by weight of the carrier composition.
Dependencies are inferred from the claim text.