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AssigneeChemoCentryx, Inc.
InventorsKaren EBSWORTH, Yu WANG, Yibin ZENG, Penglie ZHANG, Joanne TAN
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Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof. The method include administering to a subject with IBD a combination therapy containing a therapeutically effective amount of a chemokine receptor 9 (CCR9) inhibitor compound and a therapeutically effective amount of an anti-α4β7 integrin antibody such as vedolizumab. Also provided herein is a kit containing the CCR9 inhibitor compound and anti-α4β7 integrin antibody.
A method of treating or reducing the development of inflammatory bowel disease in a mammal, said method comprising administering a suitable amount of a CCR9 chemokine receptor inhibitor with an anti-α4β7 integrin blocking antibody.
A composition for treating or reducing the development of inflammatory bowel disease in a mammal, said composition comprising a therapeutically effective amount of a CCR9 chemokine receptor inhibitor, a therapeutically effective amount of an anti-α4β7 integrin blocking antibody, and a pharmaceutically acceptable carrier or excipient.
A kit for treating or reducing the development of inflammatory bowel disease in a mammal, said kit comprising a therapeutically effective amount of a CCR9 chemokine receptor inhibitor, and a therapeutically effective amount of an anti-α4β7 integrin blocking antibody, with instructions for effective administration.
Dependencies are inferred from the claim text.