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AssigneeUniversity of Washington
InventorsDavid M. Koelle, Zhi Liu, Lawrence Corey
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A method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
1-17. (canceled)
A method for eliciting a cellular immune response to HSV-2 in a subject, the method comprising administering to the subject a pharmaceutical composition comprising:
The method of claim 1, wherein the fragment consists of the amino acid sequence DRLDNRLQL (SEQ ID NO:
A method for the treatment or prevention of an HSV infection in a subject, the method comprising administering to the subject a pharmaceutical composition comprising:
Dependencies are inferred from the claim text.