Self-assembling synthetic proteins
AssigneeIn3Bio Ltd.
InventorsKeith Alan Charlton, Erik D'Hondt, Daniel T. Verhamme
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Abstract
The present disclosure provides for a synthetic immunogenic protein for use as an immuno-modulatory agent to enhance mammalian immune reactions towards conjugated protein or peptide containing antigens that are otherwise poorly immunogenic, including but not limited to self-antigens. The chimeric immunogenic proteins of the present disclosure can be used in the treatment of many illnesses, including but not limited to cancers, infectious disease, autoimmune disease, allergies and any clinical indication involving or affected by the immune response of a mammalian host.
Claims29
A recombinant synthetic protein comprising:
- a monomeric sequence that is able to assemble into stable homomultimers.
A process of preparing a multivalent molecule comprising:
- assembling multimers from monomeric sub-units to form a synthetic protein including one or more growth factors or parts thereof.
A process of preparing a vaccine formulation comprising:
- mixing one or more single monovalent multimers together preparing a multivalent vaccine including a synthetic protein including one or more growth factors or parts thereof.
A recombinant protein, comprising:
- a polypeptide sequence;
- and a first sequence expressing at least a portion of a tumor antigen within said polypeptide sequence.
Dependencies are inferred from the claim text.