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US 2016/0095909 A1Published application
Methods of Preventing Rejection of Transplanted Tissue by Administering Anti-CD40L Antibody and Dendritic Cells Loaded with Type B Peptide
AssigneeThe Trustees of Columbia University in the City of New York
InventorsHong Jiang, Leonard Chess
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Abstract
A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term administration of non-specific immunosuppressive drugs.
Claims12
A method for preventing rejection of a tissue transplanted from a donor subject into a recipient subject comprising:
- a) administering to the recipient subject, prior to transplantation of the tissue, (i) a plurality of peripheral blood mononuclear cells (PBMCs) from the donor subject, wherein the PBMCs have been irradiated and do not proliferate in vivo, and (ii) an anti-CD40 ligand (anti-CD40L) antibody;
- and
- b) administering to the recipient subject, subsequent to transplantation of the tissue, (i) an HLA-E/IgG fusion protein, (ii) an HLA-E/type B peptide tetramer, (iii) a dendritic cell-derived, HLA-E-bearing exosome loaded with type B self peptides, or (iv) a membrane-bound, HLA-E-bearing composition comprising at least one type B peptide,
- wherein the type B self peptide comprises the amino acid sequence set forth in SEQ ID NO:
- 1.
2 more elements
Dependencies are inferred from the claim text.