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AssigneeProtalix Ltd.
InventorsYoseph SHAALTIEL, Gideon BAUM, Daniel BARTFELD, Sharon HASHMUELI, Ayala LEWKOWICZ
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A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
A method of treating a subject having Gaucher's disease comprising orally administering to said subject a therapeutically effective amount of lyophilized plant cells expressing a recombinant human glucocerebrosidase protein, thereby treating said Gaucher's disease in said subject.
A method of increasing hydrolysis of glycosphingolipid glucocerebroside in macrophages of a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of lyophilized plant cells expressing a recombinant human glucocerebrosidase protein, thereby increasing hydrolysis of glycosphingolipid glucocerebroside in macrophages of the subject.
Dependencies are inferred from the claim text.