Compositions and Methods for Induced Brown Fat Differentiation
AssigneeDana-Farber Cancer Institute, Inc.
InventorsBruce M. Spiegelman, Shingo Kajimura
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Abstract
The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm1β and C/EBPβ activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm1β and C/EBPβ expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm1β and C/EBPβ expression and/or activity.
Claims13
A method for preventing or treating obesity or an obesity-related disorder in a subject comprising inducing both Prdm16 and C/EBPβ expression and/or activity sufficient to activate brown fat cell differentiation, wherein the differentiated brown fat cells increase energy expenditure to thereby prevent or treat obesity or an obesity-related disorder in the subject.
A method for increasing energy expenditure in a mammal comprising inducing both Prdm16 and C/EBPβ expression and/or activity sufficient to activate brown fat cell differentiation in the mammal, wherein the differentiated brown fat cells promote energy expenditure thereby increasing energy expenditure in the mammal.
A method for treating obesity or an obesity-related disorder in a subject comprising administering to the subject an agent that induces expression and/or activity of both Prdm16 and C/EBPβ, wherein Prdm16 and C/EBPβ expression and/or activity increases respiration and energy expenditure to thereby treat obesity or an obesity-related disorder in the subject.
13-50. (canceled)
Dependencies are inferred from the claim text.