Multipotent neural cells
AssigneeThe McLean Hospital Corporation
InventorsOle Isacson, Jan Pruszak
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Abstract
The inventions disclosed herein are based on the identification of novel cell populations derived from human embryonic stem cells and other pluripotent cells. The inventive cell populations may be used for cell therapies for the treatment of various neurological diseases and as substrates in pharmacological assays.
Claims16
A composition comprising a substantially homogenous population of cells characterized as CD24HI/CD29LO and CD15− and a physiologically compatible solution.
A neural cell replacement therapeutic composition comprising a substantially homogenous population of cells characterized as CD24HI/CD29LO and CD15− in a matrix suitable for in vivo administration.
A method of administering to a patient in need thereof a neural cell replacement therapeutic composition comprising a substantially homogenous population of cells characterized as CD24HI/CD29LO and CD15− and a physiologically compatible solution, the method comprising:
- (a) drilling a hole and piercing the dura in a patient;
- (b) inserting a microsyringe containing said therapeutic composition into the hole;
- (c) injecting the therapeutic composition into a selected region.
Dependencies are inferred from the claim text.