Method for the treatment of obesity
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, Fred Hutchinson Cancer Research Center
InventorsStanley R. Riddell, Michael Hudecek, Christoph Rader
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Abstract
The present invention relates to therapeutic compositions for treating or preventing obesity and obesity-related disorders in a subject using immunotherapy to target and eliminate adipocytes.
Claims23
A composition, comprising primate cytolytic T lymphocytes modified to express a target-specific chimeric antigen receptor, wherein the target is a cell surface antigen preferentially expressed on an adipocyte.
A kit, comprising a container containing a nucleic acid molecule encoding a target-specific chimeric antigen receptor, wherein the target is a cell surface antigen preferentially expressed on an adipocyte;
- and instructions for modifying an isolated T lymphocyte subpopulation by transducing with the nucleic acid molecule encoding the target-specific chimeric antigen receptor.
Dependencies are inferred from the claim text.