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AssigneeThe Catholic University of Korea Industry-Academic Cooperation Foundation
InventorsKi-Yuk Chang, Eun-Ho Choo, Hyo-Eun Park, Eun-Hye Park, Dae-Seog Lim, Jun-Ho Lee
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Provided are the tolerogenic dendritic cells for treating a myocardial infarction and a method for preparing the same, and more particularly, the tolerogenic dendritic cells for treating a myocardial infarction, which can treat cardiac insufficiency that occurs by excessive remodeling of left ventricle in the heart muscle recovery process after an acute myocardial infarction, and a method for preparing the tolergenic dendritic cells. According to the present invention, the inflammatory reaction and the excessive remodeling of left ventricle in the heart muscle recovery process after a myocardial infarction can be inhibited, and thus, the incidence rate of cardiac insufficiency can be significantly reduced, thereby being effectively used for treating a myocardial infarction.
A method for preparing tolerogenic dendritic cells for treating a myocardial infarction, the method comprising culturing immature dendritic cells in a medium including TNF-α (tumor necrosis factor-α), and protein extracted from a region of a myocardial infarction of an object having a myocardial infarction or serum obtained from an object having a myocardial infarction.
A method of preventing or treating a myocardial infarction comprising administering to a subject in need thereof a pharmaceutical composition comprising tolerogenic dendritic cells as an effective component.
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