Pharmaceutical-grade ferric organic compounds, uses thereof and methods of making same
AssigneePanion & BF Biotech Inc.
InventorsKeith CHAN, Winston TOWN, David W.K. KWOK, Nikolay Mintchev STOYNOV
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Abstract
The present invention discloses pharmaceutical-grade ferric organic compounds, including ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. A manufacturing and quality control process for making a pharmaceutical-grade ferric citrate that consistently complies with the established Manufacture Release Specification is also disclosed. The pharmaceutical-grade ferric organic compounds are suitable for treating disorders characterized by elevated serum phosphate levels.
Claims23
1-35. (canceled)
A method of treating hyperphosphatemia, comprising:
- administering one or more tablets comprising ferric citrate and a pharmaceutically acceptable carrier to a subject, the tablets prepared from a form of ferric citrate having a BET active surface area of at least about 16 m2/g;
- wherein the tablets are administered to provide up to 30 grams of ferric citrate to the subject per day.
A method of treating metabolic acidosis, comprising:
- administering one or more tablets comprising ferric citrate and a pharmaceutically acceptable carrier to a subject, the tablets prepared from a form of ferric citrate having a BET active surface area of at least about 16 m2/g;
- wherein the tablets are administered to provide up to 30 grams of ferric citrate to the subject per day.
Dependencies are inferred from the claim text.