Composition and kits for inhibition of pathogenic microbial infection and methods of using the same

An antimicrobial, liquid coating composition, comprising:

• 45.0 to 99.7 wt-% of a volatile polar and/or nonpolar liquid;
• 0.10 to 50.0 wt-% of a polymer dissolved in said volatile polar and/or nonpolar liquid;
• 0.10 wt-% (1,000 ppm) to 1.0 wt-% (10,000 ppm) polymeric biguanide, and
• 0.10 wt-% (1,000 ppm) to 4.0 wt-% (40,000 ppm) of an additional antimicrobial agent, wherein a polymer coating formed from said antimicrobial, liquid coating composition provides biocidal activity for at least 24 hours against at least one opportunistic pathogen that causes necrotizing fasciitis selected from Vibrio vulnificus and Streptococcus pyrogenes.

A method of inhibiting or preventing pathogenic microbial infection, comprising:

• applying a liquid antimicrobial polymer coating formulation to a biological surface,
• wherein said polymer formulation comprises:
• 0.10 to 50.0 wt-% of a polymer dissolved in about 45.0 to 99.7 wt-% of a volatile polar and/or nonpolar liquid,
• 0.10 wt-% (1,000 ppm) to 1.0 wt-% (10,000 ppm) polymeric biguanide, and
• 0.10 wt-% (1,000 ppm) to 4.0 wt-% (40,000 ppm) of an additional antimicrobial agent;
• and
• evaporating said solvent, wherein a polymer coating formed by said evaporating provides biocidal activity for at least 24 hours against at least one opportunistic pathogen that causes necrotizing fasciitis selected from Vibrio vulnificus and Streptococcus pyrogenes.