Bet inhibition therapy for heart disease
AssigneesDana-Farber Cancer Institute, Inc., Case Western Reserve University, The Brigham and Women's Hospital, Inc.
InventorsSaptarsi M. Haldar, James E. Bradner, Jonathan D. Brown
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Abstract
Method for treating cardiac diseases using BET inhibitors including JQ1 are provided. Methods for treating cardiac hypertrophy, method for treating heart failure not arising from inflammation, methods for treating myocardial infarction, methods for cardioprotection and methods for inhibiting restenosis are described herein. The methods involve the use of effective amounts of BET inhibitors such as JQ1.
Claims29
A method of treating cardiomyopathy comprising administering to a subject in need to such treatment an amount of a BET inhibitor effective to treat the cardiomyopathy.
3-7. (canceled)
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A method for treating heart failure not arising from inflammation comprising administering to a subject in need of such treatment an amount of a BET inhibitor effective to treat the heart failure.
13-14. (canceled)
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A method for treating myocardial infarction comprising administering to a subject in need of such treatment a BET inhibitor in an amount effective to treat the myocardial infarction, wherein the BET inhibitor administration is initiated not sooner than 5 days after the myocardial infarction.
19-20. (canceled)
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A method for cardio protection comprising administering to a subject receiving a therapy that is cardio toxic a BET inhibitor in an amount effective to inhibit cardio toxicity by such therapy.
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A method for inhibiting restenosis comprising administering to a subject undergoing an angioplasty and/or receiving a stent a BET inhibitor in an amount effective to inhibit restenosis.
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In a stent for preventing stenosis or restenosis, the stent including a coating for delivering a drug agent locally to the vasculature when the stent is positioned at the vasculature, the improvement comprising a BET inhibitor included in the coating.
Dependencies are inferred from the claim text.