Loading patent…
AssigneesMerck & Cie, Bayer Intellectual Property GmbH
InventorsKai STROTHMANN, Gavin Welch SMITH, Klaus PIETRZIK, Kristina KING, Rudolf MOSER
Estimating the term…
The present invention relates to a pharmaceutical composition which comprises progestogens, preferably drospirenone, estrogens, preferably ethinylestradiol and 5-methyl-(6S)-tetrahydrofolate, can be employed as oral contraceptive and moreover prevents disorders caused by folate deficiency in the consumers, in particular cardiovascular disorders and, after conception of the embryo, congenital malformations caused by folate deficiency such as, for example, neural tube defects, ventricular valve defects, urogenital defects, and cleft lip, jaw and palate, without masking the symptoms of vitamin B12 deficiency, and at the same time even in the case of homozygous or heterozygous polymorphism of methylenetetrahydrofolate reductase facilitates unimpaired utilizability of the folate component 5-methyl-(6S)-tetrahydrofolate by the body and thus its biological activity for preventing the abovementioned congenital malformations caused by folate deficiency. In addition, a prolonged protective effect is maintained after discontinuation of the contraceptive.
(canceled)
The process of claim 44, wherein said at least one progestogen is levonorgestrel, norgestimate, norethisterone, dydrogesterone, drospirenone, 3-beta-hydroxydesogestrel, 3-ketodesogestrel (=etonogestrel), 17-deacetylnorgestimate, 19-norprogesterone, acetoxypregnenolone, allylestrenol, amgestone, chlormadinone, cyproterone, demegestone, desogestrel, dienogest, dihydrogesterone, dimethisterone, ethisterone, ethynodiol diacetate, fluorogestone acetate, gastrinone, gestodene, gestrinone, hydroxymethylprogesterone, hydroxyprogesterone, lynestrenol (=lynoestrenol), mecirogestone, medroxyprogesterone, megestrol, melengestrol, nomegestrol, norethindrone (=norethisterone), norethynodrel, norgestrel (including d-norgestrel and dl-norgestrel), norgestrienone, normethisterone, progesterone, quingestanol, (17alpha)-17-hydroxy-11-methylene-19-norpregna-4,15-dien-20-yn-3-one, tibolone, trimegestone, algestone-acetophenide, nestorone, promegestone, a 17-hydroxyprogesterone esters, 19-nor-17hydroxyprogesterone, 17alpha-ethynyltestosterone, 17alpha-ethynyl-19-nortestosterone, d-17beta-acetoxy-13beta-ethyl-17alpha-ethynylgon-4-en-3-one oxime or tanaproget.
-18. (canceled)
The process of claim 44 wherein said medicament comprises a crystalline calcium salt of 5-methyl-(6S)-tetrahydrofolic acid.
The process of claim 44 wherein said medicament comprises crystalline calcium 5-methyl-(6S)-tetrahydrofolate.
A process for preparing a medicament comprising 5-methyl-(6S)-tetrahydrofolate or a pharmaceutically acceptable salt thereof, one or more estrogens and/or progestogens, optionally vitamin B6 and/or vitamin B2, and a pharmaceutically acceptable carrier, comprising absorbing the 5-methyl-(6S)-tetrahydrofolate or a pharmaceutically acceptable salt thereof after completion of granulation.
A process for preparing a medicament
Dependencies are inferred from the claim text.