Methods and compositions for safe and effective treatment of erythema
AssigneeGalderma Research & Development
InventorsMichael GRAEBER, Christian LOESCHE, Philip FREIDENREICH, Yin-sang LIU, Matthew James LEONI
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Abstract
Improved methods and compositions for safe and effective treatment of erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical composition comprising about 0.3% to about 10% by weight of brimonidine and a pharmaceutically acceptable carrier.
Claims7
A method of treating facial erythema associated with rosacea in a subject in need thereof without causing unacceptable drug related adverse events, comprising once daily topically administering to a skin area of the subject affected by the facial erythema a topical composition comprising, relative to the total weight of the composition:
- about 0.5% by weight of brimonidine tartrate;
- about 5.0% to about 15.0% by weight of at least one polyol;
- about 0.20% to about 4.0% by weight of a gelling agent;
- and
- a pharmaceutically acceptable carrier.
The method of claim 24, wherein the topical composition comprises a first polyol and a second polyol, and the amount of each of the first and second polyols in the composition is independently about 4 to 15% by weight relative to the total weight of the composition.
A method of treating facial erythema associated with rosacea in a subject in need thereof without causing unacceptable drug related adverse events, comprising once daily topically administering to a skin area of the subject affected by the facial erythema a topical composition comprising, relative to the total weight of the composition:
- about 0.5% by weight of a brimonidine tartrate;
- about 5.0% to about 15.0% by weight of at least one polyol;
- about 0.5% to about 2.0% by weight of a gelling agent;
- and
- a pharmaceutically acceptable carrier,
- wherein the gelling agent comprises a carbomer selected from the group consisting of carbomer 934P, carbomer 974P, and carbomer 980.
Dependencies are inferred from the claim text.