Methods and compositions for treatment of hiv infection

A method of preventing or delaying a rise in viral load following cessation of treatment of human immunodeficiency virus (HIV) infection, the method comprising:

• administering to a subject infected with HIV at least three compounds collectively having the following activities:
• dampening of immune activation, wherein the dampening selectively affects the CD4 T cell response relative to the CD8 T cell response,
• inhibition of HIV replication,
• stimulation of reactivation of latent HIV, and
• inhibition of infection of CD4 T cells by HIV, wherein the compound that inhibits HIV infection of CD4 T cells is selected from the group consisting of C-C chemokine receptor type 5 (CCR5) inhibitors, C-X-X chemokine receptor type 4 (CXCR4) inhibitors, CD4 inhibitors, gp120 inhibitors, and gp41 inhibitors,
• wherein the compounds are provided in dosages reducing the number of cells infected with HIV or the viral load of HIV, relative to which is achieved using just the combination of ART and compounds which activate latent HIV,
• wherein HIV infected cells or HIV viral load is not detectable at 12 months after the end of the course of treatment.