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US 2016/0095847 A1Published application
Deuterated analogs of pridopidine useful as dopaminergic stabilizers
AssigneeTeva Pharmaceuticals International GmbH
InventorClas SONESSON
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Abstract
The present invention provides novel deuterated analogs of Pridopidine, i.e. 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine. Pridopidine is a drug substance currently in clinical development for the treatment of Huntington's disease. In other aspects the invention relates to pharmaceutical compositions comprising a deuterated analog of Pridopidine of the invention, and to therapeutic applications of these analogs.
Claims21
1-11. (canceled)
A pharmaceutical composition comprising a compound represented by Formula 1
- or a pharmaceutically acceptable salt thereof, wherein
- at least one of R1-R23 represents deuterium (D);
- and
- the remaining of R1-R23 represent hydrogen (H);
- wherein the abundance of molecules of the compound having deuterium at a position designated by the at least one of R1-R23 is substantially greater than the natural abundance of deuterium at that position.
2 more elements
Dependencies are inferred from the claim text.