Targeted polymeric conjugates and uses thereof
AssigneesRamot at Tel-Aviv University Ltd., Universita' Degli Studi Di Padova
InventorsRonit SATCHI-FAINARO, Gianfranco PASUT
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Abstract
Polymeric conjugates comprising a polymeric backbone having attached thereto a bone targeting moiety and a therapeutically active agent, wherein the bone targeting moiety is attached to one end of the polymeric backbone via a branching unit such that a molar ratio of the bone targeting moiety to the polymer is at least 2:1, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
Claims31
A conjugate comprising a polymeric backbone having attached thereto a therapeutically active agent and a bone targeting moiety, said therapeutically active agent being attached to one end of said polymeric backbone and said bone targeting moiety being attached to another end of said polymeric backbone via a branching unit, said branching unit being arranged in a dendritic structure composed of a cascade of branching moieties, wherein a molar ratio of said bone targeting moiety to said polymer and is at least 2:1.
A conjugate comprising a polymeric backbone having attached to one end thereof a bisphophonate moiety, said bisphophonate being attached to said polymeric backbone via a branching unit, said branching unit being arranged in a dendritic structure composed of a cascade of branching moieties, wherein a mol ratio of said bisphosphonate to said polymer is at least 2:1.
A conjugate comprising polymeric backbone having attached thereto a therapeutically active agent, said therapeutically active agent being attached to one end of said polymeric backbone, wherein said polymeric backbone further comprises a reactive group attached to another end of said polymeric backbone via a branching unit, said branching unit being arranged in a dendritic structure composed of a cascade of branching moieties, wherein a molar ratio of said functional group to said polymer and is at least 2:1, wherein said therapeutically active agent is useful in the treatment of a bone related disease or disorder.
Dependencies are inferred from the claim text.