Vector Delivery-Based Microbicides
AssigneeRush University Medical Center
InventorsRobert Anthony Anderson, JR., Calvin J. Chany, II
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Abstract
A new class of anti-microbial agents and methods for preventing or reducing the risk of sexually transmitted infections and/or diseases is provided. Preferably, these anti-microbial agents are also contraceptive and, thus, also prevent or reduce the risk of unplanned pregnancies. The anti-microbial agents comprise a delivery vector having anti-microbial activity (and preferably contraceptive activity) coupled with a nitric oxide donor moiety.
Claims20
A method for reducing the risk of transmission and infection by a sexually transmitted disease through sexual activity between two or more parties, said method comprising:
- applying an effective amount of an anti-microbial agent to an area of the body to be engaged in the sexual activity of at least one of the parties prior to the sexual activity and then engaging in the sexual activity, wherein the antimicrobial agent comprises:
- a covalent adduct of an H2SO4-modified mandelic acid and a nitric oxide donor,
- the nitric oxide donor consisting of a nitric oxide donor moiety and a spacer;
- the nitric oxide donor being covalently bonded through the spacer to a carbonyl carbon atom derived from a carboxyl of the H2SO4-modified mandelic acid wherein NO is released from the anti-microbial agent after applying to the area of the body.
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Dependencies are inferred from the claim text.