Branched chain fatty acids for prevention or treatment of gastrointestinal disorders
AssigneeCornell University
InventorsJames Thomas BRENNA, Rinat RAN-RESSLER
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Abstract
The present invention is directed to a method of preventing or treating a gastrointestinal condition in a subject, that includes administering one or more branched chain fatty acid to the subject under conditions effective to prevent or treat the gastrointestinal condition in the subject. The present invention is also directed to methods of promoting gastrointestinal health in a subject and propagation of probiotic organisms. Also disclosed is a formulation which includes one or more branched chain fatty acid and an aqueous phase emulsified with the one or more branched chain fatty acids, where the formulation includes over 25 wt % of the one or more branched chain fatty acid.
Claims55
A method of preventing or treating a gastrointestinal condition in a subject, said method comprising:
- selecting a subject in need of treatment of the gastrointestinal condition, and
- administering a composition comprising one or more branched chain fatty acid to the subject under conditions effective to treat the gastrointestinal condition in the subject,
- wherein the one or more branched chain fatty acid is a C11 to C26 alkyl-substituted branched chain fatty acid or mixtures thereof, wherein the gastrointestinal condition is associated with inflammation, and wherein the composition is not milk or colostrum.
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A method of treatment or prevention of necrotizing enterocolitis in a subject, said method comprising:
- selecting a subject in need of prevention or treatment of necrotizing enterocolitis, and
- administering a composition comprising one or more branched chain fatty acid to the subject under conditions effective to prevent or treat the necrotizing enterocolitis in the subject, wherein the one or more branched chain fatty acid is a C11 to C26 alkyl-substituted branched chain fatty acid or mixtures thereof, and wherein the composition is not milk or colostrum.
A method of preventing a gastrointestinal condition in a subject, said method comprising:
- selecting a subject in need of prevention of the gastrointestinal condition, and
- administering a composition comprising one or more branched chain fatty acid to the subject under conditions effective to prevent the gastrointestinal condition in the subject, wherein the one or more branched chain fatty acid is a C11 to C26 alkyl-substituted branched chain fatty acid or mixtures thereof, wherein the gastrointestinal condition is necrotizing enterocolitis or inflammatory bowel disease, and wherein the composition is not milk or colostrum.
Dependencies are inferred from the claim text.