Solid pharmaceutical dosage form for release of at least one active pharmaceutical ingredient in the oral cavity
AssigneeMcNeil Corporation
InventorsAndreas Hugerth, Katarina Lindell, Fredrik Nicklasson, Kristina Thyresson
Life of this patent
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Abstract
Solid pharmaceutical dosage form for the release of at least one Active Pharmaceutical Ingredient (API) in the oral cavity comprising a core coated by at least one film coating. The core comprises at least one API. One or more organoleptically disturbing sensations induced by one or several of the APIs and/or of inactive components of the solid pharmaceutical dosage form is/are reduced by constituents of said film coating. Said constituents comprise at least one film-forming polymer and at least one flavoring agent or at least one sweetener.
Claims18
1-26. (canceled)
A solid pharmaceutical dosage form comprising:
- a. a core, wherein the core comprises at least one Active Pharmaceutical Ingredient (API) and at least one additional component, wherein the core comprises a weight of from about 50 mg to about 2000 mg, wherein the at least one API is selected from the group consisting of anesthetics, antibiotics, anti-inflammatory drugs, anti-migraine drugs, anti-diarrheas, antiseptics, decongestants, erectile dysfunction drugs, mucolytics, muscle relaxants, anti-allergy drugs, substances for the treatment of malodour, expectorants and cough suppressants, and
- b. at least one film coating, wherein the at least one film coating comprises at least one film-forming polymer, at least one flavoring agent and at least one sweetener,
- wherein the solid pharmaceutical dosage form is selected from the group consisting of a lozenge, a sublingual tablet, a buccal tablet and an orally disintegrating tablet,
- wherein the solid pharmaceutical dosage form does not contain nicotine,
- wherein upon administration, the at least one API is capable of being completely dissolved in the oral cavity, and
- wherein one or more organoleptically disturbing sensations induced by one or more of the at least one API and/or of the at least one additional component is/are reduced by the at least one flavouring agent and the at least one sweetener.
Dependencies are inferred from the claim text.