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US 2016/0095726 A1Published application
Stents having controlled elution
AssigneeMicell Technologies, Inc.
InventorsJames B. McClain, Charles Douglas Taylor
Life of this patent
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Abstract
Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
Claims41
A device comprising
- a. a stent;
- and
- b. a coating on the stent comprising a first layer comprising at least one bioabsorbable polymer;
- a second layer comprising at least one active agent;
- and an outer layer comprising at least one bioabsorbable polymer;
- wherein each of said bioabsorbable polymer layers comprises a separately sintered bioabsorbable polymer layer;
- wherein said outer layer comprising said at least one bioabsorbable polymer is sufficiently thin so that the active agent is present in crystalline form on at least one region of an outer surface of the coating opposite the stent and wherein 50% or less of the total amount of active agent in the coating is released after 24 hours in vitro elution.
4 more elements
A device comprising
- a. a stent;
- and
- b. a coating on the stent comprising a first layer comprising at least one polymer;
- a second layer comprising at least one active agent;
- and an outer layer comprising at least one polymer;
- wherein each of said polymer layers comprises a separately sintered polymer layer;
- wherein said outer layer comprising said at least one polymer is sufficiently thin so that the active agent is present in crystalline form on at least one region of an outer surface of the coating opposite the stent and wherein between 25% and 50% of the total amount of active agent in the coating is released after 24 hours in vitro elution.
4 more elements
Dependencies are inferred from the claim text.