Interface control of semi-crystalline biopolymer films
AssigneeTufts University
InventorsFlorenzo G. Omenetto, Mark Brenckle, Benedetto Marelli, David L. Kaplan, Hu Tao
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Abstract
The present invention provides, among other things, compositions including a first silk fibroin layer, and a second silk fibroin layer, wherein at least a portion of the first silk fibroin layer is directly adhered to at least a portion of the second silk fibroin layer to form a silk-silk interface and methods of making the same.
Claims55
A multilayered composition comprising
- a first silk fibroin layer;
- and
- a second silk fibroin layer,
- wherein at least a portion of the first silk fibroin layer is directly adhered to at least a portion of the second silk fibroin layer via a silk-silk interface having a bond strength of at least 500 kPa.
The multilayered composition of any one of the above claims, wherein the multilayered composition comprises a plurality of pockets.
A method for bonding a first silk fibroin layer with a second silk fibroin layer via a silk-silk interface, the method comprising the steps of:
- contacting a first silk fibroin layer with a second silk fibroin layer;
- and
- inducing reflow of silk fibroin of the first silk fibroin layer and silk fibroin of the second silk fibroin layer to generate a silk-silk interface with a bond strength of at least 500 kPa.
A multilayered composition comprising
- a first silk fibroin layer;
- a second silk fibroin layer;
- and
- a device;
- wherein at least a portion of the first silk fibroin layer is directly adhered to at least a portion of the second silk fibroin layer via a silk-silk interface, and wherein the device is located, at least in part, between the first silk fibroin layer and the second silk fibroin layer.
-70. (canceled)
Dependencies are inferred from the claim text.