Parthenolide derivatives and their modulation of processes controlled by regulated translation
AssigneeBoard of Trustees of the University of Arkansas
InventorsNarsimha Reddy Penthala, Peter Crooks, Venumadhav Janganati
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Abstract
The present invention provides parthenolide derivatives. In particular, the present invention provides parthenolide derivatives that modulate processes controlled by regulated mRNA translation and have anticancer activity.
Claims26
A method for modulating a process controlled by regulated mRNA translation, the method comprising contacting a cell with an effective amount of a compound comprising Formula (I) or a pharmaceutically acceptable salt thereof, whereby the process controlled by regulated mRNA translation is attenuated or activated, the compound comprising Formula (I):
- wherein:
- R1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl;
- R2, R3, R6, and R7 are independently hydrogen, hydroxyl, keto, halo, amine, amide, nitro, phospho, cyano, thiol, hydrocarbyl, or substituted hydrocarbyl;
- R4, R5, and R8 are independently hydrogen, hydroxyl, halo, amine, amide, nitro, phospho, thiol, hydrocarbyl, or substituted hydrocarbyl;
- and
- ----- is a double or single bond.
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A compound comprising Formula (II) or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 is hydrocarbyl or substituted hydrocarbyl;
- R2, R3, R6, and R7 are independently hydrogen, hydroxyl, keto, halo, amine, amide, nitro, phospho, cyano, thiol, hydrocarbyl, or substituted hydrocarbyl;
- R4 is hydrogen, hydrocarbyl, or substituted hydrocarbyl;
- R5 and R8 are independently hydrogen, hydroxyl, halo, amine, amide, nitro, phospho, thiol, hydrocarbyl, or substituted hydrocarbyl;
- n is an integer from 1 to 4;
- and
- ----- is a double or single bond.
A compound comprising Formula (III) or a pharmaceutically acceptable salt thereof:
- wherein:
- ----- is a double or single bond;
- and
- R is —NR9R10, in which R9 is hydrogen and R10 is heterocyclic or substituted heterocyclic, or together R9 and R10 form heterocyclic or substituted heterocyclic when ----- is a single bond;
- or
- R is carbocyclic, substituted carbocyclic, heterocyclic, or substituted heterocyclic when ----- is a double bond.
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Dependencies are inferred from the claim text.