Thermosensitive mutants of influenza viruses
AssigneeInstitut National de la Recherche Agronomique
InventorBernard DELMAS
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Abstract
The invention relates to thermosensitive mutants of influenza viruses, containing at least one mutation localised in a flexible region of a protein of said virus, such as especially the region of the sub-unit PA of the viral polymerase corresponding to the region 197-225 of the sub-unit PA of influenza A. These viruses can be especially used for preparing attenuated living vaccines.
Claims12
A method for preparing a thermosensitive mutant of an influenza virus, characterized in that at least one synthetic mutation is introduced into a region of a gene encoding the PA, PB1, PB2, NP, HA, HE, NA, M1, M2, NS1 or NS2 protein of said virus, said mutation being located in a region of said gene corresponding to a flexible region of said protein and generating a thermosensitive mutant of said virus.
Dependencies are inferred from the claim text.