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AssigneeUniversite D'Auvergne Clermont I
InventorsJean-François BRUGERE, Guillaume BORREL, Paul William O'TOOLE, Corinne MALPUECH-BRUGERE, Monique ALRIC
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Composition containing a microorganism, preferably an Archaea, expressing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in a human cavity, such as the intestine or the vagina, for use as a medicament for treating, reducing or eliminating TMA at the level of the human cavity. In addition, a composition containing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein. These compositions are of use for treating trimethylaminuria, for treating vaginal fluids in the case of bacterial vaginosis and for reducing or eliminating odours due to TMA. These compositions are also of use for reducing the level of plasma TMAO, for preventing the formation of atheroma plaques and/or for preventing cardiovascular diseases.
A method for reducing or suppressing TMA at the human cavity in a patient in need thereof, comprising administering an effective amount of a composition containing a microorganism expressing a TMA methyltransferase, or said TMA methyltransferase, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in at least one human cavity comprising microbial flora able to produce TMA.
A method for treating trimethylaminuria, or bacterial vaginosis, comprising the administration to a patient in need thereof of an effective amount of a composition containing a microorganism expressing a TMA methyltransferase, or said TMA methyltransferase, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in at least one human cavity comprising microbial flora able to produce TMA.
A method for preventing formation of atheromatous plaques and/or cardiovascular diseases, comprising the administration to a patient in need thereof of an effective amount of a composition containing a microorganism expressing a TMA methyltransferase, or said TMA methyltransferase, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in at least one human cavity comprising microbial flora able to produce TMA.
Composition comprising a TMA methyltransferase having the SEQ ID NO:
Composition comprising a TMA methyltransferase and a corrinoid protein accepting a methyl group from TMA.
Dependencies are inferred from the claim text.