Viral proteins as immunomodulatory agents and vaccine components
AssigneeUniversity of Iowa Reseach Foundation
InventorsJack T. STAPLETON, Nirjal BHATTARAI, Jinhua XIANG, James H. MCLINDEN
Life of this patent
Estimating the term…
Abstract
The invention provides compositions and methods involving viral envelope polypeptides and peptides for use in modulating immune responses, including inhibition inflammation related to pathogenic T-cell activation. In addition, modification of the viral sequences responsible for modulating immune response provides for improved vaccine formulations.
Claims27
A method of inhibiting immune cell activation comprising administering to a mammalian subject in need thereof an RNA virus envelope peptide or polypeptide comprising an immunomodulatory domain.
10-15. (canceled)
18-19. (canceled)
A composition comprising a peptide or polypeptide comprising a peptide segment as shown in FIG. 19 or 21, formulated with a pharmaceutically acceptable carrier buffer or diluent.
22-25. (canceled)
A method of inducing an immune response in an mammalian subject comprising administering to said subject with an RNA virus envelope protein wherein said envelope protein comprises one or more modified kinase sites.
28-30. (canceled)
32-33. (canceled)
35-38. (canceled)
40-42. (canceled)
A vaccine comprising an RNA virus envelope protein having a modification in a peptide segment shown in Table 5 or FIG. 19 or 21.
44-50. (canceled)
Dependencies are inferred from the claim text.