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AssigneeCimas Limited
InventorsShalva MARDI, Rosa MARDI, Gymsher MARDI, Laura MARDI, Shimon SLAVIN
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Halogenated aliphatic carboxylic acids, salts and/or oligomers or polymers thereof, which exhibit a devitalizing effect of neoplastic tissues, are disclosed. Methods and uses that utilize these compounds for the treatment of medical conditions associated with a neoplastic tissue are also disclosed. Further disclosed are methods and uses that utilize these compounds for reducing or abolishing blood and lymph as well local dissemination of malignant neoplastic cells during a surgical removal thereof, thereby preventing recurrences and distance metastases, and/or inducing immune response to potentially malignant, pre-malignant and/or malignant cells. Further disclosed are novel oligomeric forms of halogenated aliphatic carboxylic acids, pharmaceutical compositions containing same and uses thereof.
A method of treating a medical condition associated with neoplastic tissue in a subject in need thereof, the method comprising administering to the subject a devitalizing effective amount of a compound which is 2,2-dichloropropanoic acid or a pharmaceutical acceptable salt thereof, by locally administering the compound onto and/or into said neoplastic tissue,
A method of reducing or abolishing dissemination of malignant cells into a blood and/or lymph vessel of a subject having a medical condition associated with malignant neoplastic tissue and subjected to a surgical procedure for removing at least a portion of said malignant neoplastic tissue, the method comprising administering to the subject, prior to, concomitant with or subsequent to the surgical procedure, a devitalizing effective amount of a compound which is 2,2-dichloropropanoic acid or a pharmaceutical acceptable salt thereof, by locally administering the compound onto and/or into said neoplastic tissue,
A method of treating a medical condition associated with neoplastic tissue in a subject in need thereof, the method comprising administering to the subject a devitalizing effective amount of a compound which is 2,2-dichloropropanoic acid or a pharmaceutical acceptable salt or complex thereof, said administering being performed by locally administering the compound onto and/or into said neoplastic tissue during a surgical procedure for removing at least a portion of said neoplastic tissue.
A method of reducing or abolishing dissemination of malignant cells into a blood and/or lymph vessel of a subject having a medical condition associated with malignant neoplastic tissue and subjected to a surgical procedure for removing at least a portion of said malignant neoplastic tissue, the method comprising administering to the subject, prior to, concomitant with or subsequent to the surgical procedure, a devitalizing effective amount of a compound which is 2,2-dichloropropanoic acid or a pharmaceutical acceptable salt thereof,
Dependencies are inferred from the claim text.