Anti-thrombogenic grafts
AssigneeYale University
InventorsSashka DIMITRIEVSKA, Laura NIKLASON
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Abstract
The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an anti-thrombogenic coating. The present invention also provides methods of preparing anti-thrombogenic compositions and methods of treatment comprising implanting the anti-thrombogenic compositions into a subject in need thereof.
Claims34
A composition comprising a substrate having at least one surface coated with an anti-thrombogenic coating.
A method of preparing a graft coated with an anti-thrombogenic coating, comprising the steps of:
- providing a substrate having at least one surface;
- and
- coating the at least one surface with an anti-thrombogenic coating, wherein said step of coating comprises:
- applying a first crosslinking solution to the surface;
- and
- applying a hydrogel solution to the surface, thereby providing a first layer on the surface of the substrate.
A method of treating a diseased blood vessel in a subject, comprising bypassing the diseased blood vessel by implanting into the subject an anti-thrombogenic vascular graft, comprising a substrate having a luminal surface coated with an anti-thrombogenic coating.
A method of providing vascular access in a subject, comprising implanting into the subject an anti-thrombogenic vascular graft, comprising a substrate having a luminal surface coated with an anti-thrombogenic coating.
Dependencies are inferred from the claim text.