Bluetongue virus vaccine and immunogenic compositions, methods of use and methods of producing same
AssigneeZoetis Services LLC
InventorJoan Plana Duran
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Abstract
Provided are immunogenic and vaccine compositions and methods for their preparation and use, which compositions are effective in protecting against, minimizing the severity of, preventing, and/or ameliorating infection of ruminants with Bluetongue virus. Administration to an animal of at least one dose of an adjuvanted and twice inactivated Bluetongue virus composition as disclosed herein is effective in providing immunity to the animal and protection from infection with Bluetongue virus, thereby reducing the severity of and/or preventing disease caused by one or more strains or serotypes of Bluetongue virus.
Claims5
A method of producing inactivated whole Bluetongue virus (BTV) that protects animals from viremia, the method comprising the steps of first treating the BTV with binary ethyleneimine (BEI) while the BTV remains in a complete culture, and then retreating the BTV with binary ethyleneime, wherein the BTV is inactivated and remains immunogenic.
A vaccine composition for protecting an animal against BTV, comprising an immunogenically effective amount of at least one strain of twice inactivated BTV, and a biologically acceptable carrier, wherein the composition contains cell debris from the complete culture in which said BTV was first inactivated.
Dependencies are inferred from the claim text.