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AssigneeLondon School of Hygiene and Tropical Medicine
InventorsLisa Dawson, Brendan Wren
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The invention relates to deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a pharmaceutical or veterinary composition or formulation comprising at least deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a combination therapeutic comprising at least deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a method of treating a mammal suspected of being infected with, or infected with, C. difficile comprising the use of at least deoxyribonuclease; a method of cleaning or sterilising a material or product comprising the use of at least deoxyribonuclease; and a cleaning or sterilising product impregnated with or containing at least deoxyribonuclease.
A method of treating a mammal suffering from a Clostridium difficile infection comprising administering to said mammal an effective amount of a deoxyribonuclease or a functional fragment thereof, thereby treating the Clostridium difficile infection.
A method of treating Clostridium difficile (C. difficile) biofilm formation in a mammal, comprising administering to said mammal an effective amount of a deoxyribonuclease or a functional fragment thereof, thereby degrading the C. difficile biofilm.
A method of cleaning or sterilising a material susceptible to colonisation by, or colonised with, Clostridium difficile, comprising applying to said material a deoxyribonuclease enzyme, or a functional fragment thereof.
A combination therapeutic comprising a deoxyribonuclease and at least one other therapeutic agent.
A cleaning or sterilising product comprising at least deoxyribonuclease and a suitable carrier.
Dependencies are inferred from the claim text.