Bioengineered allogeneic blood vessel
AssigneeNovahep AB
InventorsSuchitra Sumitran-Holgersson, Michael Olausson
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Abstract
The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.
Claims28
A method of preparing a bioengineered blood vessel comprising introducing whole blood comprising progenitor cells to the lumen of a tubular acellular scaffold and culturing said cells, wherein the cultured cells populate the scaffold to generate the bioengineered, blood vessel.
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A method for providing a bioengineered blood vessel graft to a subject in need thereof comprising
- a. introducing subject-derived whole blood comprising progenitor cells to the lumen of a tubular acellular scaffold;
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- b. culturing said cells on the lumen of the tubular acellular scaffold, thereby preparing the bioengineered blood vessel;
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- c. transplanting the bioengineered blood vessel to the subject.
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Dependencies are inferred from the claim text.