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US 2016/0040120 A1Published application
In Vitro-Co-Culturesystem
AssigneesKarlsruher Institut für Technologie, Ruprecht-Karls-UniversitäT Heidelberg
InventorsEric Gottwald, Stefan Giselbrecht, Patrick Wuchter, Rainer Saffrich
Life of this patent
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Abstract
The present invention relates to a three-dimensional (3D) model of a hematopoietic stem and progenitor cell (HSPC) niche, that comprises the coculture of human HSPC and human mesenchymal stromal cells in a defined 3D environment and thereby procures vital stem cell functions.
Claims15
A three-dimensional (3D) model of a hematopoietic stem cell and progenitor cells (HSPC) niche comprising:
- (a) a microcavity array having at least one microcavity
- (b) a 3D mesh formed by HSPC-supporting stroma cells in the at least one microcavity.
Dependencies are inferred from the claim text.