Systems and Methods for Microbial Resistance Zones to Selectively Present Prophylactically and Therapeutically Active Agents

A cystostomy device, comprising:

• a transcutaneous sleeve, with an outer surface and an inner surface, the outer surface lying adjacent to skin, fat, muscle or other biological tissue, and the inner surface defining a path;
• at least one microbe resistance zone of the transcutaneous sleeve;
• a flange adapted to reduce contamination of the outer surface of said transcutaneous sleeve;
• a catheter defining a passage for the flow of fluids from the bladder to a surface of the patient's skins, the path of the inner surface of the transcutaneous sleeve allows passage of catheter;
• and
• an anchor adapted for implantation into biological tissue;
• wherein the transcutaneous sleeve is removably connected to the anchor and the flange and the drainage tube is removably connectable to the anchor.

A catheter, comprising:

• a first end extending to an outer surface of a patient;
• a transcutaneous section connected to the first end;
• a second end extending into the bladder lumen of a patient;
• and
• at least one microbe resistance zone selected from the group of:
• a microbe resistance zone of the first end, a microbe resistance zone of the transcutaneous section, a microbe resistance zone of the second end, and combinations.

A urinary catheter comprising:

• a first end extending from an exterior surface of a patient,
• a second end extending into the bladder lumen or other intra-corporeal space of said patient or animal, and
• a transcutaneous section connecting said first end to said second end;
• wherein said transcutaneous section further comprises
• an interior surface defining a pathway for the flow of fluids from the bladder lumen to the exterior of said patient,
• an exterior surface;
• and
• a plurality of microbe resistance zones comprising a first microbe resistance zone containing an anti-biofilm surface modulation and a second microbe resistance zone selected from the group consisting of anti-biofilm surface modulations, non-elutable molecular agents, nanochannel delivered molecular agents, and elutable molecular agents.