Anti-inflammatory pharmaceutical composition comprising benzopyranyl tetracycles

A method of treating inflammation-related disease, comprising the administration of a therapeutically effective amount of an anti-inflammatory pharmaceutical composition, wherein the anti-inflammatory pharmaceutical composition comprises a compound represented by the following Chemical Formula 1 as an active ingredient:

• wherein,
• n of (R1)n is an integer of 1 to 4, with the proviso that when n is 2 or greater, R1, which is identical or different, each is independently a hydrogen atom;
• hydroxy;
• halogen;
• C1˜C6 linear or branched alkyl;
• C3˜C10 cycloalkyl;
• C1˜C6 linear or branched alkoxy;
• C2˜C20 heterocycloalkyl containing N, O or S as a heteroatom;
• phenyl, unsubstituted or substituted with at least one selected from the group consisting of a halogen atom, amino, nitryl, nitro, C1˜C30 alkyl, C2˜C30 alkenyl, C1˜C30 alkoxy, C3˜C30 cycloalkyl, C3˜C30 heterocycloalkyl containing N, O or S as a heteroatom, C6˜C30 aryl, and C5˜C30 heteroaryl containing N, O or S as a heteroatom;
• benzyl, unsubstituted or substituted with at least one selected from the group consisting of a halogen atom, amino, nitryl, nitro, C1˜C30 alkyl, C2˜C30 alkenyl, C1˜C30 alkoxy, C3˜C30 cycloalkyl, C3˜C30 heterocycloalkyl containing N, O or S as a heteroatom, C6˜C30 aryl, and C5˜C30 heteroaryl containing N, O or S as a heteroatom;
• benzoyl;
• C1˜C30 alkyl amino;
• C2˜C30 dialkyl amino;
• or C1˜C30 alkoxy,
• R2 and R2′, which may be identical or different, are each a hydrogen atom;
• hydroxy;
• halogen;
• C1˜C6 linear or branched alkyl;
• C3˜C10 cycloalkyl;
• C1˜C6 linear or branched alkoxy;
• C2˜C20 heterocycloalkyl containing N, O or S as a heteroatom;
• phenyl, unsubstituted or substituted with at least one selected from the group consisting of a halogen atom, amino, nitryl, nitro, C1˜C30 alkyl, C2˜C30 alkenyl, C1˜C30 alkoxy, C3˜C30 cycloalkyl, C3˜C30 heterocycloalkyl containing N, O or S as a heteroatom, C6˜C30 aryl, and C5˜C30 heteroaryl containing N, O or S as a heteroatom;
• N-acetyl-4′-piperidyl;
• N-propyl-4′-piperidyl;
• or —(CH2)mX wherein m is an integer of 0 to 20, X is C2˜C30 alkylester, C1˜C30 alkylamide, C2˜C30 alkylether, or carboxylic acid;
• or R2 and R2′ may form a ring, together,
• R3 is a hydrogen atom;
• C1˜C6 linear or branched alkyl;
• C3˜C10 cycloalkyl;
• C1˜C6 linear or branched alkoxy;
• phenyl, unsubstituted or substituted with at least one selected from the group consisting of a halogen atom, amino, nitryl, nitro, C1˜C30 alkyl, C2˜C30 alkenyl, C1˜C30 alkoxy, C3˜C30 cycloalkyl, C3˜C30 heterocycloalkyl containing N, O or S as a heteroatom, C6˜C30 aryl, and C5˜C30 heteroaryl containing N, O or S as a heteroatom;
• C2˜C20 heterocycloalkyl containing N, O or S as a heteroatom;
• benzyl, unsubstituted or substituted with at least one selected from the group consisting of a halogen atom, amino, nitryl, nitro, C1˜C30 alkyl, C2˜C30 alkenyl, C1˜C30 alkoxy, C3˜C30 cycloalkyl, C3˜C30 heterocycloalkyl containing N, O or S as a heteroatom, C6˜C30 aryl, and C5˜C30 heteroaryl containing N, O or S as a heteroatom;
• p-methylphenyl, m-methylphenyl, o-methylphenyl;
• p-tert-butylethylphenyl, m-tert-butylethylphenyl, or o-tert-butylethylphenyl;
• p-methoxyphenyl, m-methoxyphenyl, or o-methoxyphenyl;
• p-fluorophenyl, m-fluorophenyl, or o-fluorophenyl;
• p-iodophenyl, m-iodophenyl, or o-iodophenyl;
• p-nitrophenyl, m-nitrophenyl, or o-nitrophenyl;
• p-chlorophenyl;
• m-chlorophenyl, or o-chlorophenyl;
• or p-bromophenyl, m-bromophenyl, or o-bromophenyl.