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US 2016/0033493 A1Published application
Filtration device for assays
AssigneeSilicon BioDevices, Inc.
InventorOctavian FLORESCU
Life of this patent
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Abstract
A device and method for filtering blood is disclosed herein. The device can filter blood and attach analytes within the blood to magnetic particles. The analytes can then be strongly bound to an analyzing device by a magnetic force. The analytes can then be counted by the analyzing device and the result can be displayed.
Claims20
A device for analyzing a biological fluid sample comprising:
- a porous material configured to receive and filter the biological fluid resulting in a filtrate comprising a first target analyte;
- dried reagents comprising, functionalized magnetic particles that react with the first target analyte,
- wherein the resulting filtrate rehydrates the dry reagents allowing the magnetic particles to react with the first analyte;
- an exposed surface of an integrated circuit having a sensor area, wherein the sensor area of the surface is functionalized to react with the first target analyte;
- a capillary that delivers filtrate to the surface of the integrated circuit;
- wherein the magnetic particles sediment to the surface of the integrated circuit,
- wherein the integrated circuit comprises integrated conductors and integrated sensors, and
- wherein sensors integrated in the integrated circuit are used to detect specifically bound magnetic particles without necessitating another detecting device.
5 more elements
A stand-alone device for analyzing a biological fluid sample comprising:
- a membrane filter configured to receive and filter the biological fluid resulting in a filtrate comprising a first target analyte;
- dried reagents comprising functionalized magnetic particles that react with the first target analyte,
- wherein the resulting filtrate rehydrates the dry reagents allowing the magnetic particles to react with the first analyte;
- an exposed surface of an integrated circuit having a sensor area,
- wherein the surface of the integrated circuit is functionalized to react with the first target analyte;
- a capillary that delivers filtrate to the surface of the integrated circuit,
- wherein the magnetic particles sediment to the surface of the integrated circuit,
- wherein sensors integrated in the integrated circuit are used to detect specifically bound magnetic particles;
- a digital display to report the results;
- and
- a battery.
8 more elements
Dependencies are inferred from the claim text.