Back to results
US 2016/0032344 A1Published application
Polysialic acid, blood group antigens and glycoprotein expression in prokaryotes
AssigneeGlycobia, Inc.
InventorsJudith H Merritt, Adam C Fisher, Brian S Hamilton, Matthew P DeLisa
Life of this patent
Estimating the term…
Abstract
The invention described herein generally relates to glycoengineering host cells for the production of glycoproteins for therapeutic use. Host cells are modified to express biosynthetic glycosylation pathways. Novel prokaryotic host cells are engineered to produce N-linked glycoproteins wherein the glycoproteins comprise polysialic acid or blood group antigens.
Claims27
A recombinant host cell comprising GalNAc transferase activity and galactosyltransferase activity;
- wherein the host cell produces an oligosaccharide composition comprising one or more GalNAc, galactose or galactose-GalNAc residues linked to a lipid carrier.
Dependencies are inferred from the claim text.