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US 2016/0031946 A1Published application
Multi-epitopic vaccine
AssigneeHopitaux Universitaires De Geneve
InventorsMADIHA SABIHA DEROUAZI, PAUL R. WALKER, PIERRE-YVES DIETRICH
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Abstract
The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4+ epitope; and (iii) at least one CD8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases.
Claims20
An isolated polypeptide comprising:
- (i) a protein transduction domain consisting of ZEBRA consisting of amino acids residues 178-220 of ZEBRA or a fragment thereof or a variant thereof having at least one conservatively substituted amino acid from the native sequence, that retains the capacity of internalization,
- (ii) at least one CD4+ epitope(s);
- and
- (iii) at least one CD8+ epitope(s).
1 more element
An isolated polynucleotide encoding a polypeptide comprising:
- (i) a protein transduction domain consisting of ZEBRA consisting of amino acids residues 178-220 of ZEBRA or a fragment thereof or a variant thereof having at least one conservatively substituted amino acid from the native sequence, that retains the capacity of internalization,
- (ii) at least one CD4+ epitope(s);
- and
- (iii) at least one CD8+ epitope(s).
1 more element
Dependencies are inferred from the claim text.