Compounds for inducing proliferation and differentiation of cells, and methods of use thereof

A method of inducing proliferation of one or more primary cells, the method comprising contacting the one or more primary cells with a compound selected from the group consisting of:

• Compound 109 (PH1, or 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one);
• Compound 110 ((1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide);
• Compound 111 ((1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane carboxamide);
• Compound 112 (1-((9H-carbazol-4-yl)oxy)-3-((2-(2-methoxyphenoxy)ethyl)amino) propan-2-ol);
• Compound 113 (3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine);
• Compound 114 (2-(2-(1,3-dioxoisoindolin-2-yl)acetamido)acetic acid);
• a compound of Formula (I):
• wherein in (I):
• W is H, F, Cl, Br, I, OH, lower alkyl or lower alkoxy;
• X is F, Cl, Br or I;
• Y and Z are independently C(═O) or S(═O)2;
• R1 is lower alkyl;
• each occurrence of R2 is independently selected from the group consisting of H, OH, F, Cl, Br, I, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, NH2, acylamino, amido, carboxyl, alkoxycarbonyl, acyloxy, formyl, acyl, thioester, carbamate, urea, sulfonate, sulfamoyl, sulfone, sulfonamide, CN, NO2, and alkylthio;
• and,
• n is 0, 1, 2, 3, 4 or 5;
• a compound of Formula (II):
• wherein in (II):
• W is H, F, Cl, Br, I, OH, lower alkyl or lower alkoxy;
• X is F, Cl, Br or I;
• each occurrence of R is independently H or lower alkyl;
• R31 is H or lower alkyl;
• and,
• R32 is amido, carboxyl, alkoxycarbonyl or sulfonamide;
• a compound of Formula (III):
• wherein in (III):
• G is C(R)2, O or N(R);
• each occurrence of Q is independently O or N(R);
• each occurrence of R is independently H or lower alkyl;
• each occurrence of Y is independently C(═O) or S(O)2;
• and,
• R41 is lower alkyl or lower alkoxy;
• a compound of Formula (IV):
• wherein in (IV):
• each occurrence of R is independently H or lower alkyl;
• Q is a bond, O or N(R);
• Y is C(═O) or S(O)2;
• R11 is substituted or unsubstituted alkyl, cycloalkyl, aryl, heteroaryl or aralkyl;
• R12 is H or lower alkyl;
• R13 is H or substituted or unsubstituted lower alkyl;
• R14 is H, F, Cl, Br, I, substituted or unsubstituted aryl or heteroaryl, or —CC—R16, where R16 is substituted or unsubstituted aminoalkyl, alkoxyalkyl, aryl or heteroaryl;
• each occurrence of R15 is independently OH, F, Cl. Br, I, NH2, CN, NO2, lower alkyl, or lower alkoxy;
• and,
• n is 0, 1 or 2;
• a compound of Formula (V):
• wherein in (V):
• each occurrence of R is independently H or lower alkyl;
• Q is a bond, O or NR;
• Y is C═O or S(O)2, preferably C═O;
• R21 is substituted or unsubstituted alkyl, aralkyl, cycloalkyl, aryl or heteroaryl;
• R22 is H or lower alkyl;
• R23 is H or substituted or unsubstituted lower alkyl;
• and,
• R25 is H, OH, F, Cl, Br, I, lower alkyl, lower alkoxy, NH2, CN, or NO2;
• enantiomers or diastereoisomers thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, and any combinations thereof,
• whereby contacting the one or more primary cells with the at least one compound induces proliferation of the one or more primary cells.