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US 2016/0031778 A1Published application
Process and systems for obtaining 1,4-butanediol from fermentation broths
AssigneeGenomatica, Inc.
InventorsSVB Janardhan GARIKIPATI, Michael JAPS, Ishmael M. SONICO
Life of this patent
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Abstract
A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol product.
Claims39
A process of purifying 1,4-butanediol (1,4-BDO) comprising:
- (a) subjecting a crude 1,4-BDO mixture to a first column distillation procedure to remove materials with a boiling point lower than 1,4-BDO from the crude 1,4-BDO mixture to produce a first 1,4-BDO-containing product stream;
- and
- (b) subjecting the first 1,4-BDO-containing product stream to a second column distillation procedure to remove materials with boiling points higher than 1,4-BDO as a first high-boilers stream, to produce a purified 1,4-BDO product, wherein the purified 1,4-BDO product is collected from a side-draw of the second column distillation procedure.
A system for purifying 1,4-BDO comprising:
- a first distillation column receiving a crude 1,4-BDO mixture and generating a first stream of materials with boiling points lower than 1,4-BDO and a 1,4-BDO-containing product stream;
- a second distillation column receiving the 1,4-BDO-containing product stream at a feed point and generating a first stream of materials with boiling points higher than 1,4-BDO, a second stream of materials with boiling points lower than 1,4-BDO, and a purified 1,4-BDO product from a side-draw;
- and
- a wiped-film evaporator receiving the first stream of materials with boiling points higher than 1,4-BDO and generating a distillate, wherein the distillate is fed to the second distillation column.
1 more element
A system for purifying 1,4-BDO comprising:
- a first distillation column receiving a crude 1,4-BDO mixture generating a first stream of materials with boiling points lower than 1,4-BDO and a first 1,4-BDO-containing product stream;
- an intermediate distillation column receiving the first 1,4-BDO-containing product stream generating a first stream of materials with boiling points higher than 1,4-BDO, and a second 1,4-BDO-containing product stream;
- a wiped-film evaporator receiving the first stream of materials with boiling points higher than 1,4-BDO and generating a distillate, wherein the distillate is fed to the intermediate distillation column;
- and
- a second distillation column receiving the second 1,4-BDO-containing product stream at a feed point and generating a second stream of materials with boiling points lower than 1,4-BDO, a second stream of materials with boiling points higher than 1,4-BDO, and a purified 1,4-BDO product from a side-draw.
2 more elements
A process of producing a 1,4-BDO product comprising:
- culturing a modified non-naturally occurring organism to produce a 1,4-BDO in a fermentation broth;
- subjecting the fermentation broth to a separation procedure to obtain a separated 1,4-BDO product, wherein the separation procedure consists a first filtration and a second filtration, wherein the first filtration is microfiltration or ultrafiltration, wherein the second filtration is nanofiltration;
- and
- subjecting the separated 1,4-BDO product to a polishing ion exchange using a polishing ion exchange resin.
1 more element
A system for purifying 1,4-BDO comprising:
- a first distillation column receiving a crude 1,4-BDO mixture generating a first stream of materials with boiling points lower than 1,4-BDO and a first 1,4-BDO-containing product stream;
- a first intermediate distillation column receiving the first 1,4-BDO-containing product stream generating a first stream of materials with boiling points higher than 1,4-BDO, and a second 1,4-BDO-containing product stream;
- a wiped-film evaporator receiving the first stream of materials with boiling points higher than 1,4-BDO and generating a distillate, wherein the distillate is fed to the first intermediate distillation column;
- a second intermediate distillation column receiving the second 1,4-BDO-containing product stream generating a second stream of materials with boiling points lower than 1,4-BDO, and a third 1,4-BDO-containing product stream;
- and
- a second distillation column receiving the third 1,4-BDO-containing product stream at a feed point and generating a second stream of materials with boiling points higher than 1,4-BDO, and a purified 1,4-BDO product.
3 more elements
The system of claim 32, wherein the ratio of the purge rate of the first stream of materials with boiling points higher than 1,4-BDO from the first intermediate column to the feed rate of first the first 1,4-BDO-containing product stream BDO to the first intermediate column is between 0.5 to 0.2.
A process of purifying 1,4-butanediol (1,4-BDO) comprising:
- (a) subjecting a crude 1,4-BDO mixture to a first column distillation procedure to remove materials with a boiling point lower than 1,4-BDO from the crude 1,4-BDO mixture to produce a first 1,4-BDO-containing product stream;
- (b) subjecting the first 1,4-BDO-containing product stream to a first intermediate column distillation procedure to remove materials with a boiling point higher than 1,4-BDO, as a first high boilers stream, to produce a second 1,4-BDO-containing product stream;
- (c) subjecting the first high-boilers stream to wiped-film evaporation (WFE) to produce a WFE distillate and subjecting the WFE distillate to step (b);
- (d) subjecting the second 1,4-BDO-containing product stream to a second intermediate column distillation procedure to remove materials with a boiling point lower than 1,4-BDO, to produce a third 1,4-BDO-containing product stream;
- and
- (e) subjecting the third 1,4-BDO-containing product stream to a second column distillation procedure to remove materials with boiling points higher than 1,4-BDO as a second high-boilers stream, to produce a purified 1,4-BDO product.
3 more elements
Dependencies are inferred from the claim text.