Anti-mycobacterial vaccines
AssigneeUniversite De Geneve
InventorsElodie Anne Françoise BELNOUE, Stéphanie Gabrielle DARBRE ABDELRAHMAN, Arun Thomas KAMATH, Paul LAMBERT, Claire-Anne SIEGRIST-JULLIARD, Daniel David PINSCHEWER
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Abstract
Provided herein are genetically modified arenaviruses suitable as vaccines against mycobacterial infections. The invention also relates to pharmaceutical compositions and methods for the prevention and treatment of mycobacterial infections. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of preventing and treating infections in Mycobacterium tuberculosis.
Claims42
An infectious, replication-deficient arenavirus particle comprising a nucleotide sequence encoding a mycobacterial antigen or a fragment thereof.
An infectious, replication-deficient arenavirus particle comprising a genomic segment, wherein the genomic segment comprises a nucleotide sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:1
An infectious, replication-deficient arenavirus particle comprising a genomic segment, wherein the genomic segment comprises a nucleotide sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, at least 99%, or 100% identical to the sequence of nucleotide 1639 to 3315 of SEQ ID NO:11 or 1640 to 3316 of SEQ ID NO:12, and wherein the genomic segment comprises a nucleotide sequence encoding a mycobacterial antigen.
An infectious, replication-deficient arenavirus particle comprising a genomic segment, wherein the genomic segment comprises a nucleotide sequence encoding an expression product whose amino acid sequence is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, at least 99%, or 100% identical to the amino acid sequence encoded by 1639 to 3315 of SEQ ID NO:11 or 1640 to 3316 of SEQ ID NO:12, and wherein the genomic segment comprises a nucleotide sequence encoding a mycobacterial antigen.
An isolated nucleic acid, wherein the nucleic acid encodes an arenavirus genomic segment of an arenavirus wherein one open reading frame of the genomic segment is deleted or functionally inactivated and wherein the genomic segment encodes a mycobacterial antigen.
An isolated nucleic acid encoding an arenavirus genomic segment, wherein the genomic segment comprises a nucleotide sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the sequence of nucleotide 1639 to 3315 of SEQ ID NO:11 or 1640 to 3316 of SEQ ID NO:12, and wherein the genomic segment comprises a nucleotide sequence encoding a mycobacterial antigen.
An isolated nucleic acid encoding an arenavirus genomic segment, wherein the genomic segment comprises a nucleotide sequence encoding an expression product whose amino acid sequence is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, at least 99%, or 100% identical to the amino acid sequence encoded by 1639 to 3315 of SEQ ID NO:11 or 1640 to 3316 of SEQ ID NO:12, and wherein the genomic segment comprises a nucleotide sequence encoding a mycobacterial antigen.
A nucleic acid encoding a protein comprising an amino acid sequence that is at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence of SEQ ID NO:3.
An protein comprising an amino acid sequence that is at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.