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US 2016/0022756 A1Published application
Method for preparing pharmaceutical compositions of rhizomes from alpinia galanga or alpinia conchigera having a high content of 1's-1'-acetoxychavicol acetate (aca)
AssigneeNerthus Aps
InventorsHenrik Byrial Jakobsen, Ina Giversen
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Abstract
The present invention relates to a method for preparing a granulate composition of rhizomes from Alpinia galanga or Alpinia conchigera having a high and stable content of 1′S-1′-acetoxychavicol acetate and low microbiological count, which is suitable for preparing orally ingestible dosage forms such as tablets or capsules.
Claims17
A method for preparing a granulate composition of Alpinia galanga or Alpinia conchigera, said method comprising the steps of:
- a. providing a dry preparation of Alpinia galanga or Alpinia conchigera which is milled;
- b. suspending said dry preparation in an essentially pure organic solvent,
- c. wet granulation of said dry preparation with a binder dissolved in an essentially pure organic solvent, said binder solution being essentially devoid of water;
- d. removing the organic solvent;
- e. providing a final milling;
- said steps b-d) being performed at a temperature lower than 50° C., such as lower than 40° C., such as lower than 35° C., such as 30° C.
3 more elements
A granulate composition of rhizomes from Alpinia galanga or Alpinia conchigera, said dry preparation comprising:
- i) all the constituent parts of Alpinia galanga or Alpinia conchigera in essentially anhydrous, or desiccated form;
- ii) at least 1% 1'S-1′-acetoxychavicol acetate.
Dependencies are inferred from the claim text.