Back to results
US 2016/0016880 A1Published application
Bicyclo [2.2.1] acid gpr120 modulators
AssigneeBristol-Myers Squibb Company
InventorsYan Shi, Peter T.W. Cheng, Ying Wang, Shung C. Wu, Hao Zhang
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds of Formula (I): (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.
Claims13
A compound of Formula (I):
- or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
- L1 is independently L4-O or O-L4;
- L2 is independently a hydrocarbon linker substituted with 0-2 Rc, a hydrocarbon-heteroatom linker substituted with 0-2 Rc, or —(CH2)1-2—(C3-4 cycloalkyl substituted with 0-2 Rc)—(CH2)0-1—;
- wherein said hydrocarbon linker has one to six carbon atoms and may be straight or branched, saturated or unsaturated;
- and said hydrocarbon-heteroatom linker has one to four carbon atoms and one group selected from O, —CO—, S, —SO—, —SO2—, NH, N(C1-4 alkyl), —CONH—, and —NHCO—;
- L4 is independently a bond or a hydrocarbon linker;
- wherein said hydrocarbon linker has one to four carbon atoms and may be straight or branched;
- R1 is independently selected from:
- C6-10 carbocycle and a 5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S(O)p;
- wherein said carbocycle and heterocycle are substituted with 0-4 R3 and 0-1 R4;
- R2 independently selected from:
- OH, CO2H, CO2(C1-4 alkyl), CONReNRf, and —CONHSO2Rf;
- R3, at each occurrence, is independently selected from:
- halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 haloalkylthio, and NO2;
- R4 is independently -L3-R5;
- L3 is independently selected from:
- a bond, O, and C(═O);
- R5 is independently selected from:
- phenyl and a 5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S(O)p;
- wherein each ring moiety is substituted with 0-2 Ra;
- Ra, at each occurrence, is independently selected from:
- halogen, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkyl;
- Rb, at each occurrence, is independently selected from:
- H, C1-4 alkyl, and —(CH2)0-2-(phenyl substituted with 0-3 Rd);
- Rc, at each occurrence, is independently selected from:
- ═O, halogen, OH, C1-4 alkyl, C1-4 haloalkyl, and C1-4 alkoxy;
- Rd, at each occurrence, is independently selected from:
- halogen, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkyl;
- Re, at each occurrence, is independently selected from:
- H and C1-4 alkyl;
- Rf, at each occurrence, is independently selected from:
- H, C1-4 alkyl, —(CH2)0-2-phenyl, and C3-6 cycloalkyl substituted with 1-2 OH;
- Re and Rf may be combined with the nitrogen atom to which they are attached to form a 4- to 6-membered heterocyclic ring comprising carbon atoms and 1 additional heteroatom selected from N, NRb, O, and S;
- wherein said heterocycle is substituted with and 0-1 OH;
- and
- p is, independently at each occurrence, selected from 0, 1, and 2.
33 more elements
Dependencies are inferred from the claim text.