Antibodies to argininosuccinate synthase and related methods
AssigneeTDW Group
InventorsWei He, Yunyun Guo, Bor-Wen Wu
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Abstract
Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to argininosuccinate synthase, and related compositions, kits, and methods of use thereof, for instance, as companion diagnostics to identify suitable subjects for arginine deprivation or depletion therapies such as ADI-PEG 20 and other arginine deiminase (ADI) polypeptide-based therapies.
Claims50
An isolated antibody, or antigen-binding fragment thereof, which specifically binds to a human argininosuccinate synthase polypeptide and (a) comprises a heavy chain variable region (VH) sequence that comprises complementary determining region VHCDR1, VHCDR2, and VHCDR3 sequences set forth respectively in SEQ ID NOs:7, 8, and 9, and a light chain variable region (VL) sequence that comprises complementary determining region VLCDR1, VLCDR2, and VLCDR3 sequences set forth respectively in SEQ ID NOs:10, and 12;
- or (b) competitively inhibits the binding of (a) to the human argininosuccinate synthase polypeptide.
Dependencies are inferred from the claim text.