Methods for preparation of lycopenes from c15-wittig salts and methods for purification of high all-e containing and high 6z containing c15-wittig salts
AssigneeAllied Biotech, Inc.
InventorsHaw-Shyi CHIU, Po-Wei LIN
Life of this patent
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Abstract
The present invention relates to methods for preparation of lycopenes, especially to lycopenes with high all-E contents or high 6Z contents from C15-Wittig slats mixtures. (with high all-E-contents and high 6Z-contents, respectively). C15-Wittig slats mixtures are purified and 6Z-C15-Wittig salts are extracted from the mixtures. The extracted 6Z-C15-Wittig salts are, used in the synthesis of lycopenes with high 6Z contents and the residues are used in the synthesis of lycopenes with high All-E contents.
Claims27
A method for purification of C15-Wittig salts to obtain high all-E contents, comprising the steps of:
- obtaining a C15-Wittig salt cis/trans mixture;
- purifying the C15-Wittig salt cis/trans mixture to remove solvents;
- adding an aprotic solvent to the C15 Wittig salt cis/trans mixture to extract 6Z-C15-Wittig salts from the mixture;
- removing the 6Z-C15-Wittig salts from the mixture to obtain residues;
- and
- purifying the obtained residues to obtain C15-Wittig salts;
- characterized in that the aprotic solvent comprises acetone.
5-7. (canceled)
(canceled)
A method for purification of C15-Wittig salts to obtain high 6Z contents, comprising the steps of:
- obtaining a C15-Wittig salt cis/trans mixture;
- purifying the C15-Wittig salt cis/trans mixture to remove solvents;
- adding an aprotic solvent to the C15 Wittig salt cis/trans mixture to extract 6Z-C15-Wittig salts from the mixture;
- and
- purifying the 6Z-C15-Wittig salts to obtain C15-Wittig salts;
- characterized in that the aprotic solvent comprises acetone.
14-17. (canceled)
(canceled)
A product of lycopene crystals produced directly from a chemical synthesis process and containing an all-E content of at least 95% (HPLC area %).
A product of lycopene crystals produced directly from a chemical synthesis process and containing a 5Z content of at least 95% (HPLC area %).
(canceled)
The method according to claim 15, wherein the extraction takes place at 40° C. to 50° C. of temperature for 2 hours.
(canceled)
Dependencies are inferred from the claim text.