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US 2015/0369816 A1Published application
Polypeptide Immobilization
AssigneeThe University of Chicago
InventorsMilan MRKSICH, Christian HODNELAND
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Abstract
The present invention provides a method, comprising (a) providing a reactant ligand attached to a substrate; (b) contacting the substrate with a fusion polypeptide, said fusion polypeptide comprising a capture polypeptide fused to a display polypeptide under conditions such that said reactant ligand covalently binds to said capture polypeptide; and (c) analyzing said display polypeptide.
Claims17
1-15. (canceled)
A system, comprising:
- (a) a plurality of hydrolase reactant ligands for a hydrolase attached to a substrate;
- (b) a plurality of fusion polypeptides, wherein each of said fusion polypeptides comprises a hydrolase capture polypeptide fused to a display polypeptide, wherein the hydrolase capture polypeptide is capable of covalently binding to said hydrolase reactant ligands.
Dependencies are inferred from the claim text.