Viral nanoparticle multimers
AssigneeCase Western Reserve University
InventorsNicole F. Steinmetz, Amy M. Wen
Life of this patent
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Abstract
Virus particle multimers and methods of making and using such virus particle multimer are described. Virus particle multimers are constructed by preparing a plurality of asymmetrically functionalized virus particles bearing one or more functional groups and contacting the asymmetrically functionalized virus particles with a first linker molecule that reacts with the functional groups to form a virus particle multimer that includes a plurality of asymmetrically functionalized virus particles connected by the linker molecule. The asymmetrically functionalized virus particles are typically prepared by attaching the virus particles to a support surface to allow asymmetrical functionalization to be introduced.
Claims24
A method of making a virus particle multimer, comprising
- preparing a plurality of asymmetrically functionalized virus particles bearing one or more functional groups, and
- contacting the asymmetrically functionalized virus particles with a first linker molecule that reacts with the functional groups to form a virus particle multimer comprising a plurality of asymmetrically functionalized virus particles connected by the linker molecule.
A method of delivering a cargo molecule to a cell, comprising contacting the cell with a virus particle multimer loaded with the cargo molecule.
Dependencies are inferred from the claim text.