US 2015/0353607 A1 · Glycopeptide Compound Or Pharmaceutical Salt Thereof And Method For Preparing Same, And Pharmaceutical Compositions And Applications Thereof

Glycopeptide Compound Or Pharmaceutical Salt Thereof And Method For Preparing Same, And Pharmaceutical Compositions And Applications Thereof

AssigneesZhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory, Shanghai Health Creation Center Ltd. for Biopharmaceuticals R&D, Shanghai Institute of Pharmaceutical Industry

InventorsDingfeng Zhang, Yuanyuan Ge, Mei Ge, Weicheng Zhou, Wei Wei, Shunli Zhang, Lingao Ruan, Zhenren Liu, Chang Shao

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Abstract

The present invention provides a glycopeptide compound or pharmaceutically acceptable salt thereof as shown in Formula (I) or (II), and a method for preparing same, and pharmaceutical compositions and applications thereof, wherein the definition of R1, R2, R3, R4, R5 is the same as that of the specification. The glycopeptide compound of the present invention has in-vitro antibacterial activity and has important significance for development of new antibacterial agents.

Claims18

Dependent claims

A glycopeptide compound or pharmaceutically acceptable salt thereof of Formula (I) or (II),

wherein:
R1 is H, n-decyl, or a mono-substituted benzyl substituted by halogen, methoxy or isopropyl;
R2 is H, Wat methoxycarbonyl or n-decyl;
R3 is H or n-decyl;
NR4R5 is diethylamino, n-butylamino, morpholino, or phosphonic acid methylene amino;

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/655,830Filed 26 Dec 2013

Priority

CN 201210581733.X27 Dec 2012

Published

10 Dec 2015

Term ends

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Classification12 codes

C07K 9/006
Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof: the peptide…
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
C07K 9/008
The peptide sequence being part of a ring structure: directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin,…
A61K 38/00
Medicinal preparations containing peptides