Chromatography Media For Purifying Vaccines And Viruses
OwnerJohn Amara, Benjamin Cacace +2inventors
InventorsJohn Amara, Benjamin Cacace, David Yavorsky, John Boyle
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Abstract
Adsorptive media for chromatography, particularly ionexchange chromatography, derived from a shaped fiber, useful for purifying viruses. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Surface pendant functional groups can be added that provides ion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of viruses, such as influenza.
Claims9
A process of purifying a virus in a sample, comprising contacting said sample with a bed of fiber media, the fibers in said media comprising a body region and a plurality of projections extending from said body region, said fibers having imparted thereon functionality enabling chromatography.
Dependencies are inferred from the claim text.